06/J203

 

Defectos de mineralización ósea en pacientes pediátricos con artritis crónica

Abnormalities in bone mineralization in children with juvenile chronic artritis

 

Director: DIUMENJO, Marta Silvia

E-mail: diumenji@fmed2.uncu.edu.ar

 

Co-Director: VALLÉS, Roberto

 

Integrantes: GALLARDO, Ángela; SARAVÍ, Fernando; PÁEZ, Miguel Ángel; BISCARDI, Mónica; CESTINO, Laura; PAVES, Cynthia; DI BLASIS, Gladys

 

Resumen Técnico

Objetivo: detectar la presencia de osteoporosis temprana en pacientes pediátricos con artritis crónica y analizar cuales son los probables mecanismos involucrados en su desarrollo.

Pacientes y métodos: estudio prospectivo realizado con pacientes que tienen diagnóstico de Artritis Crónica Juvenil de reciente comienzo. Tiempo de seguimiento 24 meses. Se valorará modificaciones del remodelamiento óseo y cambios densitométricos que pudieran experimentar entre el inicio de su enfermedad y luego de alcanzado el control de la misma con un tratamiento protocolizado.

Idénticas observaciones se realizaran en forma conjunta sobre un grupo control.

Los resultados obtenidos seran sometidos a evaluación estadística.

Beneficios esperados: Un conocimiento mas profundo en la genesis de la osteoporosis en ésta población en particular , podría ayudarnos a tomar medidas de prevención mas precoces y conductas terapeúticas más eficientes.

 

Summary

Osteoporosis is characterized by loss of both bon mass and microarchitectural integrity, resulting in an increased risk of fractures with associated morbidity and mortally. Awareness of this condition is increasing in pediatrics, including pediatric rheumatology.

Reduced bone mineral density in now well recognized in children and young adult with juvenile chronic arthritis (JCA) and in multifactorial in origin, occurring early in active disease.

Low bone mass is not restricted to patients treated with corticosteroids.

Considering the high bone turnover and enhanced skeletal remodeling that occurs in children, children with might be at particular risk for developing osteoporosis.

One strategy in prevention de osteoporosis is to maximize peak bone mass with interventions focused during the childhood and adolescent year, taking advantage of the unique window of opportunity to maximize bone mass accrual, maximize peak bone mass, and theoretically decrease fracture risk for life.

Optimizing calcium intake and control of disease activity , is sound management for children with (JCA).

Objective: to assess bone mineral density (BMD) and bone turnover in children with JCA and identify predictors factors of reduced BMD.

Patients and methods: include pediatric patients with JCA and control subjects matched for sex and age.

Densitometry by dual x-ray absorptiometry (DXA), markers of bone metabolism and disease status will be performances in both group during two years of study.